TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3KÎ³/SGK1 pathway-dependent M2 macrophage polarisation.

Wu, Yirong; Zhan, Siyao; Chen, Lian; Sun, Mingrui; Li, Miaofu; Mou, Xuanting; Zhang, Zhen; Xu, Linhao; Xu, Yizhou

Wu, Yirong; Zhan, Siyao; Chen, Lian; Sun, Mingrui; Li, Miaofu; Mou, Xuanting; Zhang, Zhen; Xu, Linhao; Xu, Yizhou.

Afiliação

Wu Y; Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, 310006, China.
Zhan S; Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, 310006, China.
Chen L; Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, 310006, China.
Sun M; Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, 310006, China.
Li M; Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, 310006, China.
Mou X; Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, 310006, China.
Zhang Z; Department of Orthopedics, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, 310006, China.
Xu L; Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, 310006, China. xulinhaoluck@163.com.
Xu Y; Translational Medicine Research Center, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, 310006, China. xulinhaoluck@163.com.

J Transl Med ; 21(1): 544, 2023 08 14.

Article em En | MEDLINE | ID: mdl-37580750

Assuntos

Fibrilação Atrial; Animais; Camundongos; Fibrilação Atrial/genética; Fibrose; Átrios do Coração/patologia; Leucócitos Mononucleares/metabolismo; Macrófagos/metabolismo; Fatores de Necrose Tumoral/metabolismo; Humanos

Palavras-chave

Atrial fibrillation; Cardiac fibrosis; Tumour necrosis factor superfamily protein 14

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fibrilação Atrial Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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