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Piperic acid derivative as a molecular modulator to accelerate the IAPP aggregation process and alter its antimicrobial activity.
Chan, Ai-Ci; Shan, Pei-Ya; Wu, Men-Hsin; Lin, Pin-Han; Tsai, Chang-Shun; Hsu, Chia-Chien; Chiu, Ting-Hsiang; Hsu, Ting-Wei; Yeh, Yi-Cheun; Lai, Yun-Ju; Liu, Wei-Min; Tu, Ling-Hsien.
Afiliação
  • Chan AC; Department of Chemistry, National Taiwan Normal University, Taipei 116, Taiwan. litu@gapps.ntnu.edu.tw.
  • Shan PY; Department of Chemistry, National Taiwan Normal University, Taipei 116, Taiwan. litu@gapps.ntnu.edu.tw.
  • Wu MH; Department of Chemistry, National Taiwan Normal University, Taipei 116, Taiwan. litu@gapps.ntnu.edu.tw.
  • Lin PH; Department of Chemistry, Fu Jen Catholic University, New Taipei City 242, Taiwan. 133797@mail.fju.edu.tw.
  • Tsai CS; Department of Chemistry, National Taiwan Normal University, Taipei 116, Taiwan. litu@gapps.ntnu.edu.tw.
  • Hsu CC; Department of Chemistry, National Taiwan Normal University, Taipei 116, Taiwan. litu@gapps.ntnu.edu.tw.
  • Chiu TH; Institute of Polymer Science and Engineering, National Taiwan University, Taipei, 106, Taiwan.
  • Hsu TW; Department of Life Science, National Taiwan Normal University, Taipei 116, Taiwan. yunjulai@ntnu.edu.tw.
  • Yeh YC; Institute of Polymer Science and Engineering, National Taiwan University, Taipei, 106, Taiwan.
  • Lai YJ; Department of Life Science, National Taiwan Normal University, Taipei 116, Taiwan. yunjulai@ntnu.edu.tw.
  • Liu WM; Department of Chemistry, Fu Jen Catholic University, New Taipei City 242, Taiwan. 133797@mail.fju.edu.tw.
  • Tu LH; Department of Chemistry, National Taiwan Normal University, Taipei 116, Taiwan. litu@gapps.ntnu.edu.tw.
Chem Commun (Camb) ; 59(71): 10660-10663, 2023 Aug 31.
Article em En | MEDLINE | ID: mdl-37581279
ABSTRACT
Piperic acid derivatives were found to affect the islet amyloid polypeptide (IAPP) aggregation process. Structure-activity relationship studies revealed that PAD-13 was an efficient molecular modulator to accelerate IAPP fibril formation by promoting primary and secondary nucleation and reducing its antimicrobial activity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polipeptídeo Amiloide das Ilhotas Pancreáticas / Anti-Infecciosos Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polipeptídeo Amiloide das Ilhotas Pancreáticas / Anti-Infecciosos Idioma: En Ano de publicação: 2023 Tipo de documento: Article