Metal-Free Synthesis of 2H-Indazole Skeletons by Photochemistry or Thermochemistry.
J Org Chem
; 88(17): 12341-12356, 2023 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-37582245
ABSTRACT
A simple and tuned synthesis of a 2H-indazole skeleton under metal-free conditions was developed. Under visible-light irradiation at room temperature, 2-((aryl/alkyl/H)ethynyl))aryltriazenes reacted with arylsulfinic acids to afford 3-functionalized 2H-indazoles without extra photocatalyst via an electron donor-acceptor complex. In the presence of arylsulfinic acid, 2-(ethynyl)aryltriazenes underwent an intramolecular oxidation/cyclization to provide 2H-indazole-3-carbaldehydes at 50 °C in air.
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MEDLINE
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En
Ano de publicação:
2023
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Article