Synthesis of (22R)-, (22S)-22-Fluoro-, and 22,22-Difluoro-25-hydroxyvitamin D3 and Effects of Side-Chain Fluorination on Biological Activity and CYP24A1-Dependent Metabolism.

Kawagoe, Fumihiro; Mototani, Sayuri; Yasuda, Kaori; Takeuchi, Akiko; Mano, Hiroki; Kakuda, Shinji; Saitoh, Hiroshi; Sakaki, Toshiyuki; Kittaka, Atsushi

Synthesis of (22R)-, (22S)-22-Fluoro-, and 22,22-Difluoro-25-hydroxyvitamin D₃ and Effects of Side-Chain Fluorination on Biological Activity and CYP24A1-Dependent Metabolism.

Kawagoe, Fumihiro; Mototani, Sayuri; Yasuda, Kaori; Takeuchi, Akiko; Mano, Hiroki; Kakuda, Shinji; Saitoh, Hiroshi; Sakaki, Toshiyuki; Kittaka, Atsushi.

Afiliação

Kawagoe F; Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.
Mototani S; Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.
Yasuda K; Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan.
Takeuchi A; Teijin Institute for Bio-medical Research, Teijin Pharma Ltd., Hino, Tokyo 191-8512, Japan.
Mano H; Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan.
Kakuda S; Teijin Institute for Bio-medical Research, Teijin Pharma Ltd., Hino, Tokyo 191-8512, Japan.
Saitoh H; Teijin Institute for Bio-medical Research, Teijin Pharma Ltd., Hino, Tokyo 191-8512, Japan.
Sakaki T; Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama 939-0398, Japan.
Kittaka A; Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.

J Org Chem ; 88(17): 12394-12408, 2023 Sep 01.

Article em En | MEDLINE | ID: mdl-37590101

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article