Hederagenin inhibits high glucose-induced fibrosis in human renal cells by suppression of NLRP3 inflammasome activation through reducing cathepsin B expression.

Yang, Guohua; Yang, Wang; Jiang, Hairong; Yi, Qing; Ma, Wei

Yang, Guohua; Yang, Wang; Jiang, Hairong; Yi, Qing; Ma, Wei.

Afiliação

Yang G; Department of Endocrinology, Pingxiang Chinese Medicine Hospital, Pingxiang, China.
Yang W; Department of Internal Medicine, Pingxiang Chinese Medicine Hospital, Pingxiang, China.
Jiang H; Dispensary, Pingxiang Chinese Medicine Hospital, Pingxiang, China.
Yi Q; Department of Internal Medicine, Pingxiang Chinese Medicine Hospital, Pingxiang, China.
Ma W; Department of Pharmacy, Ninth Hospital of Xi'an, Xi'an, China.

Chem Biol Drug Des ; 102(6): 1409-1420, 2023 12.

Article em En | MEDLINE | ID: mdl-37599208

Assuntos

Nefropatias Diabéticas; Inflamassomos; Humanos; Inflamassomos/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Nefropatias Diabéticas/tratamento farmacológico; Catepsina B; Fibrose; Glucose; RNA Mensageiro

Palavras-chave

CTSB; diabetic nephropathy; fibrosis; hederagenin; renal cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nefropatias Diabéticas / Inflamassomos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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