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A stable and replicable neural signature of lifespan adversity in the adult brain.
Holz, Nathalie E; Zabihi, Mariam; Kia, Seyed Mostafa; Monninger, Maximillian; Aggensteiner, Pascal-M; Siehl, Sebastian; Floris, Dorothea L; Bokde, Arun L W; Desrivières, Sylvane; Flor, Herta; Grigis, Antoine; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Brühl, Rüdiger; Martinot, Jean-Luc; Martinot, Marie-Laure Paillère; Orfanos, Dimitri Papadopoulos; Paus, Tomás; Poustka, Luise; Fröhner, Juliane H; Smolka, Michael N; Vaidya, Nilakshi; Walter, Henrik; Whelan, Robert; Schumann, Gunter; Meyer-Lindenberg, Andreas; Brandeis, Daniel; Buitelaar, Jan K; Nees, Frauke; Beckmann, Christian; Banaschewski, Tobias; Marquand, Andre F.
Afiliação
  • Holz NE; Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands. nathalie.holz@zi-mannheim.de.
  • Zabihi M; Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands. nathalie.holz@zi-mannheim.de.
  • Kia SM; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany. nathalie.holz@zi-mannheim.de.
  • Monninger M; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. nathalie.holz@zi-mannheim.de.
  • Aggensteiner PM; Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands.
  • Siehl S; Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.
  • Floris DL; MRC Unit for Lifelong Health & Ageing, University College London (UCL), London, UK.
  • Bokde ALW; Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands.
  • Desrivières S; Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.
  • Flor H; Department of Psychiatry, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Grigis A; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Garavan H; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Gowland P; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig Holstein, Kiel University, Kiel, Germany.
  • Heinz A; Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, the Netherlands.
  • Brühl R; Department for Cognitive Neuroscience, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands.
  • Martinot JL; Methods of Plasticity Research, Department of Psychology, University of Zurich, Zurich, Switzerland.
  • Martinot MP; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
  • Orfanos DP; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Paus T; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Poustka L; Department of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.
  • Fröhner JH; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
  • Smolka MN; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
  • Vaidya N; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
  • Walter H; Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
  • Whelan R; Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Berlin, Germany.
  • Schumann G; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Developmental Trajectories & Psychiatry'; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France.
  • Meyer-Lindenberg A; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Developmental Trajectories & Psychiatry'; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette, France.
  • Brandeis D; Institut National de la Santé et de la Recherche Médicale, INSERM U1299 'Developmental Trajectories & Psychiatry'; Université Paris-Saclay, Ecole Normale supérieure Paris-Saclay, CNRS, Centre Borelli, Gif-sur-Yvette; and AP-HP.Sorbonne Université, Department of Child and Adolescent Psychiatry, P
  • Buitelaar JK; NeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
  • Nees F; Departments of Psychiatry and Neuroscience and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
  • Beckmann C; Departments of Psychiatry and Psychology, University of Toronto, Toronto, Ontario, Canada.
  • Banaschewski T; Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, Göttingen, Germany.
  • Marquand AF; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.
Nat Neurosci ; 26(9): 1603-1612, 2023 09.
Article em En | MEDLINE | ID: mdl-37604888
ABSTRACT
Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, the long-term effects of adversity on brain structure and the association of individual neurobiological heterogeneity with behavior have yet to be elucidated. Here we estimated normative models of structural brain development based on a lifespan adversity profile in a longitudinal at-risk cohort aged 25 years (n = 169). This revealed widespread morphometric changes in the brain, with partially adversity-specific features. This pattern was replicated at the age of 33 years (n = 114) and in an independent sample at 22 years (n = 115). At the individual level, greater volume contractions relative to the model were predictive of future anxiety. We show a stable neurobiological signature of adversity that persists into adulthood and emphasize the importance of considering individual-level rather than group-level predictions to explain emerging psychopathology.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Longevidade / Transtornos Mentais Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Longevidade / Transtornos Mentais Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article