A Supramolecular Naphthalene Diimide Radical Anion with Efficient NIR-II Photothermal Conversion for E. coli-Responsive Photothermal Therapy.
Angew Chem Int Ed Engl
; 62(41): e202308513, 2023 10 09.
Article
em En
| MEDLINE
| ID: mdl-37607898
ABSTRACT
We report a supramolecular naphthalene diimide (NDI) radical anion with efficient NIR-II photothermal conversion for E.â
coli-responsive photothermal therapy. The supramolecular radical anion (NDI-2CB[7])â
- , which is obtained from the E.â
coli-induced in situ reduction of NDI-2CB[7] neutral complex, formed by the host-guest interaction between an NDI derivative and cucurbit[7]uril (CB[7]), exhibits unexpectedly strong NIR-II absorption and remarkable photothermal conversion capacity in aqueous solution. The NIR-II absorption is caused by the self-assembly of NDI radical anions to form supramolecular dimer radicals in aqueous solution, which is supported by theoretically predicted spectra. The (NDI-2CB[7])â
- demonstrates excellent NIR-II photothermal antimicrobial activity (>99 %). This work provides a new approach for constructing NIR-II photothermal agents and non-contact treatments for bacterial infections.
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Base de dados:
MEDLINE
Assunto principal:
Escherichia coli
/
Terapia Fototérmica
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article