Targeting nonalcoholic fatty liver disease via gut microbiome-centered therapies.
Gut Microbes
; 15(1): 2226922, 2023.
Article
em En
| MEDLINE
| ID: mdl-37610978
ABSTRACT
Humans possess abundant amounts of microorganisms, including bacteria, fungi, viruses, and archaea, in their gut. Patients with nonalcoholic fatty liver disease (NAFLD) exhibit alterations in their gut microbiome and an impaired gut barrier function. Preclinical studies emphasize the significance of the gut microbiome in the pathogenesis of NAFLD. In this overview, we explore how adjusting the gut microbiome could serve as an innovative therapeutic strategy for NAFLD. We provide a summary of current information on untargeted techniques such as probiotics and fecal microbiota transplantation, as well as targeted microbiome-focused therapies including engineered bacteria, prebiotics, postbiotics, and phages for the treatment of NAFLD.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Probióticos
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Microbiota
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Hepatopatia Gordurosa não Alcoólica
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Microbioma Gastrointestinal
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article