Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network.
Sci Adv
; 9(34): eadh9570, 2023 08 25.
Article
em En
| MEDLINE
| ID: mdl-37624889
ABSTRACT
Salient cues, such as the rising sun or availability of food, entrain biological clocks for behavioral adaptation. The mechanisms underlying entrainment to food availability remain elusive. Using single-nucleus RNA sequencing during scheduled feeding, we identified a dorsomedial hypothalamus leptin receptor-expressing (DMHLepR) neuron population that up-regulates circadian entrainment genes and exhibits calcium activity before an anticipated meal. Exogenous leptin, silencing, or chemogenetic stimulation of DMHLepR neurons disrupts the development of molecular and behavioral food entrainment. Repetitive DMHLepR neuron activation leads to the partitioning of a secondary bout of circadian locomotor activity that is in phase with the stimulation and dependent on an intact suprachiasmatic nucleus (SCN). Last, we found a DMHLepR neuron subpopulation that projects to the SCN with the capacity to influence the phase of the circadian clock. This direct DMHLepR-SCN connection is well situated to integrate the metabolic and circadian systems, facilitating mealtime anticipation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Receptores para Leptina
/
Relógios Circadianos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article