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Sodium Nitrite Attenuates Reduced Activity of Vascular Matrix Metalloproteinase-2 and Vascular Hyper-Reactivity and Increased Systolic Blood Pressure Induced by the Placental Ischemia Model of Preeclampsia in Anesthetized Rats.
Martins, Laisla Zanetoni; da Silva, Maria Luiza Santos; Rodrigues, Serginara David; Gomes, Sáskia Estela Biasotti; Molezini, Laura; Rizzi, Elen; Montenegro, Marcelo Freitas; Dias-Junior, Carlos Alan.
Afiliação
  • Martins LZ; Department of Biophysics and Pharmacology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu 18618-689, Brazil.
  • da Silva MLS; Department of Biophysics and Pharmacology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu 18618-689, Brazil.
  • Rodrigues SD; Department of Biophysics and Pharmacology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu 18618-689, Brazil.
  • Gomes SEB; Department of Biophysics and Pharmacology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu 18618-689, Brazil.
  • Molezini L; Unit of Biotechnology, University of Ribeirao Preto (UNAERP), Ribeirao Preto 14096-900, Brazil.
  • Rizzi E; Unit of Biotechnology, University of Ribeirao Preto (UNAERP), Ribeirao Preto 14096-900, Brazil.
  • Montenegro MF; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 10691 Stockholm, Sweden.
  • Dias-Junior CA; Department of Biophysics and Pharmacology, Institute of Biosciences, Sao Paulo State University (UNESP), Botucatu 18618-689, Brazil.
Int J Mol Sci ; 24(16)2023 Aug 15.
Article em En | MEDLINE | ID: mdl-37628999
ABSTRACT
Preeclampsia is a maternal hypertension disorder associated with vascular dysfunction and fetal and placental growth restrictions. Placental ischemia is suggested as the primary trigger of preeclampsia-associated impairments of both endothelium-derived nitric oxide (NO) and the vascular activity of extracellular matrix metalloproteinase-2 (MMP-2). Reduced uteroplacental perfusion pressure (RUPP) is a placental ischemia model of preeclampsia. Reduction of sodium nitrite to NO may occur during ischemic conditions. However, sodium nitrite effects in the RUPP model of preeclampsia have not yet been investigated. Pregnant rats were divided into four groups normotensive pregnant rats (Norm-Preg), pregnant rats treated with sodium nitrite (Preg + Nitrite), preeclamptic rats (RUPP), and preeclamptic rats treated with sodium nitrite (RUPP + Nitrite). Maternal blood pressure and fetal and placental parameters were recorded. Vascular function, circulating NO metabolites, and the gelatinolytic activity of vascular MMP-2 were also examined. Sodium nitrite attenuates increased blood pressure, prevents fetal and placental weight loss, counteracts vascular hyper-reactivity, and partially restores NO metabolites and MMP-2 activity. In conclusion, sodium nitrite reduction to NO may occur during RUPP-induced placental ischemia, thereby attenuating increased blood pressure, fetal and placental growth restriction, and vascular hyper-reactivity associated with preeclampsia and possibly restoring NO and MMP-2 activity, which underlie the blood pressure-lowering effects.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Nitrito de Sódio Limite: Animals / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Nitrito de Sódio Limite: Animals / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2023 Tipo de documento: Article