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Small molecule nitroalkenes inhibit RAD51-mediated homologous recombination and amplify triple-negative breast cancer cell killing by DNA-directed therapies.
Hong, Lisa; Braden, Dennis C; Zhao, Yaoning; Skoko, John J; Chang, Fei; Woodcock, Steven R; Uvalle, Crystall; Casey, Allison; Wood, Katherine; Salvatore, Sonia R; Asan, Alparslan; Harkness, Trey; Fagunloye, Adeola; Razzaghi, Mortezaali; Straub, Adam; Spies, Maria; Brown, Daniel D; Lee, Adrian V; Schopfer, Francisco; Freeman, Bruce A; Neumann, Carola A.
Afiliação
  • Hong L; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA.
  • Braden DC; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA.
  • Zhao Y; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA; School of Medicine, Tsinghua University, Beijing, China.
  • Skoko JJ; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA.
  • Chang F; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Woodcock SR; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Uvalle C; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Casey A; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA.
  • Wood K; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Salvatore SR; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Asan A; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA.
  • Harkness T; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA.
  • Fagunloye A; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA.
  • Razzaghi M; Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA, USA.
  • Straub A; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Spies M; Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA, USA.
  • Brown DD; Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Lee AV; Institute for Precision Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
  • Schopfer F; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Freeman BA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA.
  • Neumann CA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA; Women's Cancer Research Center, UPMC Hillman Cancer Center, Magee-Women's Research Institute, Pittsburgh, PA, USA. Electronic address: neumannc@upmc.edu.
Redox Biol ; 66: 102856, 2023 10.
Article em En | MEDLINE | ID: mdl-37633047
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Mama Triplo Negativas Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias de Mama Triplo Negativas Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article