Pachymic acid protects hepatic cells against oxygen-glucose deprivation/reperfusion injury by activating sirtuin 1 to inhibit HMGB1 acetylation and inflammatory signaling.

Xue, Chengbiao; Xu, Zhigao; Liu, Zhongzhong; Zeng, Cheng; Ye, Qifa

Xue, Chengbiao; Xu, Zhigao; Liu, Zhongzhong; Zeng, Cheng; Ye, Qifa.

Afiliação

Xue C; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natu
Xu Z; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natu
Liu Z; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natu
Zeng C; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natu
Ye Q; Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, National Quality Control Center for Donated Organ Procurement, Hubei Key Laboratory of Medical Technology on Transplantation, Hubei Clinical Research Center for Natu

Chin J Physiol ; 66(4): 239-247, 2023.

Article em En | MEDLINE | ID: mdl-37635483

Assuntos

Proteína HMGB1; Traumatismo por Reperfusão; Ratos; Animais; Humanos; Oxigênio/metabolismo; Oxigênio/farmacologia; Glucose/metabolismo; Sirtuína 1/metabolismo; Sirtuína 1/farmacologia; Ratos Sprague-Dawley; Acetilação; Proteína HMGB1/metabolismo; Proteína HMGB1/farmacologia; Simulação de Acoplamento Molecular; Traumatismo por Reperfusão/prevenção & controle; Traumatismo por Reperfusão/metabolismo; Estresse Oxidativo; Hepatócitos/metabolismo; Apoptose

Palavras-chave

HMGB1 acetylation; liver injury; oxygen-glucose deprivation/reperfusion; pachymic acid

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Proteína HMGB1 Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google