Maternal androgen excess inhibits fetal cardiomyocytes proliferation through RB-mediated cell cycle arrest and induces cardiac hypertrophy in adulthood.

Huo, Y; Wang, W; Zhang, J; Xu, D; Bai, F; Gui, Y

Huo, Y; Wang, W; Zhang, J; Xu, D; Bai, F; Gui, Y.

Afiliação

Huo Y; National Children's Medical Center, Children's Hospital of Fudan University, Fudan University, Shanghai, 201102, China.
Wang W; National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, 399 Wanyuan Road, Minhang, Shanghai, 201102, China.
Zhang J; Guangzhou Center for Disease Control and Prevention, Guangzhou, 510080, China.
Xu D; National Children's Medical Center, Children's Hospital of Fudan University, Fudan University, Shanghai, 201102, China.
Bai F; National Health Commission (NHC) Key Laboratory of Neonatal Diseases, Fudan University, 399 Wanyuan Road, Minhang, Shanghai, 201102, China.
Gui Y; Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai, 201102, China.

J Endocrinol Invest ; 47(3): 603-617, 2024 Mar.

Article em En | MEDLINE | ID: mdl-37642904

Assuntos

Androgênios; Miócitos Cardíacos; Humanos; Adulto; Gravidez; Feminino; Animais; Camundongos; Androgênios/efeitos adversos; Androsterona; Pontos de Checagem do Ciclo Celular; Proliferação de Células; Proteínas de Ciclo Celular; Di-Hidrotestosterona; Cardiomegalia/induzido quimicamente

Palavras-chave

Androgen excess; Cardiac function; Cardiomyocytes' proliferation; DOHaD

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Miócitos Cardíacos / Androgênios Limite: Adult / Animals / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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