Radical-mediated sulfonylative/thiolative cyclization of biaryl enones to phenanthrone derivatives.
Org Biomol Chem
; 21(36): 7327-7338, 2023 Sep 20.
Article
em En
| MEDLINE
| ID: mdl-37646289
ABSTRACT
An approach for the assembly of phenanthrone derivatives bearing all carbon quaternary centres has been developed through visible light-promoted tandem sulfonylation/intramolecular-arylation of biaryl enones with sulfonyl chlorides. A series of sulfonylated 10,10-dialkylphenanthrones were obtained in good yields. In addition, the approach has been extended to thiotrifluoromethyl (SCF3) and thiocyanato (SCN) radicals to obtain the corresponding phenanthrones under oxidative conditions. The synthetic utility was also illustrated by the scalability and further transformations of the product.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article