Xuebijing injection protects sepsis induced myocardial injury by mediating TLR4/NF-&#954;B/IKK&#945; and JAK2/STAT3 signaling pathways.

Kang, Xiang-Fei; Lu, Xiao-Li; Bi, Cheng-Fei; Hu, Xiao-Dong; Li, Ying; Li, Jin-Kui; Yang, Li-Shan; Liu, Jia; Ma, Lei; Zhang, Jun-Fei

Xuebijing injection protects sepsis induced myocardial injury by mediating TLR4/NF-κB/IKKα and JAK2/STAT3 signaling pathways.

Kang, Xiang-Fei; Lu, Xiao-Li; Bi, Cheng-Fei; Hu, Xiao-Dong; Li, Ying; Li, Jin-Kui; Yang, Li-Shan; Liu, Jia; Ma, Lei; Zhang, Jun-Fei.

Afiliação

Kang XF; Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan 750000, Ningxia, China.
Lu XL; Laboratory Animal Centre, Ningxia Medical University, Yinchuan 750000, Ningxia, China.
Bi CF; Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan 750000, Ningxia, China.
Hu XD; School of Clinical Medicine, Ningxia Medical University, Yinchuan 750000, Ningxia, China.
Li Y; Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan 750000, Ningxia, China.
Li JK; Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan 750000, Ningxia, China.
Yang LS; Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan 750000, Ningxia, China.
Liu J; Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan 750000, Ningxia, China.
Ma L; Medical Experimental Center, General Hospital of Ningxia Medical University, Yinchuan 750000, Ningxia, China.
Zhang JF; Department of Emergency Medical, General Hospital of Ningxia Medical University, Yinchuan 750000, Ningxia, China.

Aging (Albany NY) ; 15(16): 8501-8517, 2023 08 30.

Article em En | MEDLINE | ID: mdl-37650558

Assuntos

Traumatismos Cardíacos; Sepse; Animais; Ratos; NF-kappa B; Quinase I-kappa B; Caspase 3; Caspase 9; Receptor 4 Toll-Like; Interleucina-6; Inibidores de Poli(ADP-Ribose) Polimerases; Fator de Necrose Tumoral alfa; Proteína X Associada a bcl-2; Transdução de Sinais

Palavras-chave

JAK2/STAT3; Xuebijing; apoptosis; inflammation; sepsis induced myocardial injury

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sepse / Traumatismos Cardíacos Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sepse / Traumatismos Cardíacos Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article