Overlapping representations of food and social stimuli in mouse VTA dopamine neurons.
Neuron
; 111(22): 3541-3553.e8, 2023 11 15.
Article
em En
| MEDLINE
| ID: mdl-37657441
ABSTRACT
Dopamine neurons of the ventral tegmental area (VTADA) respond to food and social stimuli and contribute to both forms of motivation. However, it is unclear whether the same or different VTADA neurons encode these different stimuli. To address this question, we performed two-photon calcium imaging in mice presented with food and conspecifics and found statistically significant overlap in the populations responsive to both stimuli. Both hunger and opposite-sex social experience further increased the proportion of neurons that respond to both stimuli, implying that increasing motivation for one stimulus increases overlap. In addition, single-nucleus RNA sequencing revealed significant co-expression of feeding- and social-hormone-related genes in individual VTADA neurons. Taken together, our functional and transcriptional data suggest overlapping VTADA populations underlie food and social motivation.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Área Tegmentar Ventral
/
Neurônios Dopaminérgicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article