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Spatial multimodal analysis of transcriptomes and metabolomes in tissues.
Vicari, Marco; Mirzazadeh, Reza; Nilsson, Anna; Shariatgorji, Reza; Bjärterot, Patrik; Larsson, Ludvig; Lee, Hower; Nilsson, Mats; Foyer, Julia; Ekvall, Markus; Czarnewski, Paulo; Zhang, Xiaoqun; Svenningsson, Per; Käll, Lukas; Andrén, Per E; Lundeberg, Joakim.
Afiliação
  • Vicari M; Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory, Stockholm, Sweden.
  • Mirzazadeh R; Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory, Stockholm, Sweden.
  • Nilsson A; Department of Pharmaceutical Biosciences, Spatial Mass Spectrometry, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Shariatgorji R; Department of Pharmaceutical Biosciences, Spatial Mass Spectrometry, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Bjärterot P; Department of Pharmaceutical Biosciences, Spatial Mass Spectrometry, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
  • Larsson L; Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory, Stockholm, Sweden.
  • Lee H; Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, Stockholm, Sweden.
  • Nilsson M; Department of Biochemistry and Biophysics, Stockholm University, Science for Life Laboratory, Stockholm, Sweden.
  • Foyer J; Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory, Stockholm, Sweden.
  • Ekvall M; Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory, Stockholm, Sweden.
  • Czarnewski P; Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory, Stockholm, Sweden.
  • Zhang X; Department of Clinical Neuroscience, Section of Neurology, Karolinska Institutet, Stockholm, Sweden.
  • Svenningsson P; Department of Clinical Neuroscience, Section of Neurology, Karolinska Institutet, Stockholm, Sweden.
  • Käll L; Basic and Clinical Neuroscience, King's College London, London, UK.
  • Andrén PE; Department of Gene Technology, KTH Royal Institute of Technology, Science for Life Laboratory, Stockholm, Sweden.
  • Lundeberg J; Department of Pharmaceutical Biosciences, Spatial Mass Spectrometry, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. per.andren@uu.se.
Nat Biotechnol ; 2023 Sep 04.
Article em En | MEDLINE | ID: mdl-37667091
We present a spatial omics approach that combines histology, mass spectrometry imaging and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low-molecular-weight metabolites across tissue regions. The workflow is compatible with commercially available Visium glass slides. We demonstrate the potential of our method using mouse and human brain samples in the context of dopamine and Parkinson's disease.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article