Elucidation of Carboxylesterase Mediated Pharmacokinetic Interactions between Irinotecan and Oroxylin A in Rats via Physiologically Based Pharmacokinetic Modeling.

Zhang, Jun; Zhang, Yufeng; Lai, Yuen Sze; Song, Qianbo; Xiao, Min; Ji, Xiaoyu; Yan, Xiaoyu; Zuo, Zhong

Zhang, Jun; Zhang, Yufeng; Lai, Yuen Sze; Song, Qianbo; Xiao, Min; Ji, Xiaoyu; Yan, Xiaoyu; Zuo, Zhong.

Afiliação

Zhang J; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.
Zhang Y; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.
Lai YS; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.
Song Q; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.
Xiao M; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.
Ji X; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.
Yan X; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.
Zuo Z; School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR. joanzuo@cuhk.edu.hk.

Pharm Res ; 40(11): 2627-2638, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37667147

Assuntos

Flavonoides; Fígado; Ratos; Animais; Irinotecano/farmacocinética; Fígado/metabolismo; Intestinos; Camptotecina/farmacocinética

Palavras-chave

PBPK; carboxylesterase; irinotecan; oroxylin A

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flavonoides / Fígado Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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