Heterolactone and Heterolactams A-M, Verticillane Diterpenoids with Anti-Inflammatory and Hepatoprotective Activities from the Soft Coral Heteroxenia ghardaqensis.
J Nat Prod
; 86(9): 2131-2138, 2023 09 22.
Article
em En
| MEDLINE
| ID: mdl-37672747
ABSTRACT
Fourteen new verticillane diterpenoids, heterolactone (1) and heterolactams A-M (2-14), were isolated from the soft coral Heteroxenia ghardaqensis. They structurally share the same 6/12 bicyclic carbon skeleton that is not commonly encountered in marine organisms. The structures, including the absolute configurations, were determined by extensive spectroscopic analysis, single-crystal X-ray diffraction analysis, calculated ECD spectra, and DP4+ probability analyses. Compounds 5, 8, and 9 showed anti-inflammatory activities, and 2, 8, and 12 displayed hepatoprotective activities in zebrafish assays.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antozoários
/
Diterpenos
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article