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Sleep and Pain: A Role for the Anterior Cingulate Cortex, Nucleus Accumbens, and Dopamine in the Increased Pain Sensitivity Following Sleep Restriction.
Sardi, Natalia F; Pescador, Ana C; Azevedo, Evellyn M; Pochapski, José A; Kukolj, Caroline; Spercoski, Katherinne M; Andrade, Anderson J M; da Cunha, Claudio; Fischer, Luana.
Afiliação
  • Sardi NF; Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
  • Pescador AC; Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
  • Azevedo EM; Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
  • Pochapski JA; Department of Pharmacology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil; Department of Biochemistry, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
  • Kukolj C; Department of Biochemistry, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
  • Spercoski KM; Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil; Division of Biosciences, Federal University of Parana, Palotina, Parana, Brazil.
  • Andrade AJM; Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
  • da Cunha C; Department of Pharmacology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
  • Fischer L; Department of Physiology, Division of Biological Sciences, Federal University of Parana, Curitiba, Parana, Brazil.
J Pain ; 25(2): 331-349, 2024 Feb.
Article em En | MEDLINE | ID: mdl-37673193
ABSTRACT
Persistent pain conditions and sleep disorders are public health problems worldwide. It is widely accepted that sleep disruption increases pain sensitivity; however, the underlying mechanisms are poorly understood. In this study, we used a protocol of 6 hours a day of total sleep deprivation for 3 days in rats to advance the understanding of these mechanisms. We focused on gender differences and the dopaminergic mesocorticolimbic system. The findings demonstrated that sleep restriction (SR) increased pain sensitivity in a similar way in males and females, without inducing a significant stress response. This pronociceptive effect depends on a nucleus accumbens (NAc) neuronal ensemble recruited during SR and on the integrity of the anterior cingulate cortex (ACC). Data on indirect dopaminergic parameters, dopamine transporter glycosylation, and dopamine and cyclic adenosine monophosphate (AMP)-regulated phosphoprotein-32 phosphorylation, as well as dopamine, serotonin, and norepinephrine levels, suggest that dopaminergic function decreases in the NAc and ACC after SR. Complementarily, pharmacological activation of dopamine D2, but not D1 receptors either in the ACC or in the NAc prevents SR from increasing pain sensitivity. The ACC and NAc are the main targets of dopaminergic mesocorticolimbic projections with a key role in pain modulation. This study showed their integrative role in the pronociceptive effect of SR, pointing to dopamine D2 receptors as a potential target for pain management in patients with sleep disorders. These findings narrow the focus of future studies on the mechanisms by which sleep impairment increases pain sensitivity. PERSPECTIVE This study demonstrates that the pronociceptive effect of SR affects similarly males and females and depends on a NAc neuronal ensemble recruited during SR and on the integrity of the ACC. Findings on dopaminergic function support dopamine D2 receptors as targets for pain management in sleep disorders patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dopamina / Núcleo Accumbens Tipo de estudo: Diagnostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dopamina / Núcleo Accumbens Tipo de estudo: Diagnostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2024 Tipo de documento: Article