GPR114/ADGRG5 is activated by its tethered peptide agonist because it is a cleaved adhesion GPCR.

Bernadyn, Tyler F; Vizurraga, Alexander; Adhikari, Rashmi; Kwarcinski, Frank; Tall, Gregory G

Bernadyn, Tyler F; Vizurraga, Alexander; Adhikari, Rashmi; Kwarcinski, Frank; Tall, Gregory G.

Afiliação

Bernadyn TF; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Vizurraga A; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Adhikari R; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Kwarcinski F; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Tall GG; Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA. Electronic address: gregtall@umich.edu.

J Biol Chem ; 299(10): 105223, 2023 10.

Article em En | MEDLINE | ID: mdl-37673336

Assuntos

Receptores Acoplados a Proteínas G; Transdução de Sinais; Adesão Celular; Peptídeos/farmacologia; Peptídeos/metabolismo; Ligação Proteica; Domínios Proteicos; Receptores Acoplados a Proteínas G/química; Humanos

Palavras-chave

ADGRG5; GAIN domain; adhesion G proteincoupled receptor (AGPCR); autoproteolysis; cyclic AMP (cAMP); orthosteric agonist; receptor activation; tethered peptide agonist

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Receptores Acoplados a Proteínas G Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google