Edaravone dexborneol ameliorates cognitive impairment by regulating the NF-&#954;B pathway through AHR and promoting microglial polarization towards the M2 phenotype in mice with bilateral carotid artery stenosis (BCAS).

Li, Lei; He, Guojun; Shi, Mingyu; Zhu, Juehua; Cheng, Yongqing; Chen, Yang; Chen, Jin; Xue, Qun

Edaravone dexborneol ameliorates cognitive impairment by regulating the NF-κB pathway through AHR and promoting microglial polarization towards the M2 phenotype in mice with bilateral carotid artery stenosis (BCAS).

Li, Lei; He, Guojun; Shi, Mingyu; Zhu, Juehua; Cheng, Yongqing; Chen, Yang; Chen, Jin; Xue, Qun.

Afiliação

Li L; Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, 215006, China; Department of Neurology, The First People's Hospital of Yancheng, Affiliated Hospital of Nanjing University Medical School, Yancheng, Jiangsu Province, 224005, China.
He G; Department of Neurology, The First People's Hospital of Yancheng, Affiliated Hospital of Nanjing University Medical School, Yancheng, Jiangsu Province, 224005, China.
Shi M; Department of Neurology, The First People's Hospital of Yancheng, Affiliated Hospital of Nanjing University Medical School, Yancheng, Jiangsu Province, 224005, China.
Zhu J; Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, 215006, China.
Cheng Y; Department of Neurology, The First People's Hospital of Yancheng, Affiliated Hospital of Nanjing University Medical School, Yancheng, Jiangsu Province, 224005, China.
Chen Y; Department of Neurology, The First People's Hospital of Yancheng, Affiliated Hospital of Nanjing University Medical School, Yancheng, Jiangsu Province, 224005, China.
Chen J; Department of Neurology, The First People's Hospital of Yancheng, Affiliated Hospital of Nanjing University Medical School, Yancheng, Jiangsu Province, 224005, China.
Xue Q; Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, 215006, China. Electronic address: qxue_sz@sina.com.

Eur J Pharmacol ; 957: 176036, 2023 Oct 15.

Article em En | MEDLINE | ID: mdl-37673366

Assuntos

Estenose das Carótidas; Disfunção Cognitiva; Animais; Camundongos; NF-kappa B; Edaravone/farmacologia; Microglia; Estenose das Carótidas/complicações; Estenose das Carótidas/tratamento farmacológico; Receptores de Hidrocarboneto Arílico; Fator 6 Associado a Receptor de TNF; Disfunção Cognitiva/tratamento farmacológico

Palavras-chave

Aryl hydrocarbon receptor; Cerebral small vessel disease; Cognitive dysfunction; Edaravone dexborneol; Microglia polarization; Nuclear factor-κB signalling pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estenose das Carótidas / Disfunção Cognitiva Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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