Mutational landscape and predictors of survival in head and neck mucosal melanoma.

Lehrich, Brandon M; Abiri, Arash; Nguyen, Theodore V; Bitner, Benjamin F; Tong, Charles C L; Kuan, Edward C

Lehrich, Brandon M; Abiri, Arash; Nguyen, Theodore V; Bitner, Benjamin F; Tong, Charles C L; Kuan, Edward C.

Afiliação

Lehrich BM; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Abiri A; Medical Scientist Training Program, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nguyen TV; Medical Scientist Training Program, University of California, Irvine, California, USA.
Bitner BF; Department of Otolaryngology, University of California, Irvine, California, USA.
Tong CCL; Department of Otolaryngology, University of California, Irvine, California, USA.
Kuan EC; Department of Otolaryngology, University of California, Irvine, California, USA.

Int Forum Allergy Rhinol ; 14(4): 858-861, 2024 Apr.

Article em En | MEDLINE | ID: mdl-37676479

ABSTRACT

ABSTRACT

KEY POINTS Head and neck mucosal melanomas have a diverse mutational landscape with low mutational burden. A molecular subset (â¼13%) has ROS1 mutations, which is an actionable driver mutation. ROS1-mutated patients have improved overall survival likely due to high mutational burden.

Assuntos

Melanoma; Humanos; Melanoma/genética; Proteínas Tirosina Quinases/genética; Proteínas Proto-Oncogênicas/genética; Mutação; Análise Mutacional de DNA

Palavras-chave

mucosal melanoma; patient survival; tumor genetics; tumor mutational burden

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Melanoma Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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