Adjuvant and Neoadjuvant Treatments for Resectable Hepatocellular Carcinoma.
Curr Oncol Rep
; 25(10): 1191-1201, 2023 Oct.
Article
em En
| MEDLINE
| ID: mdl-37688739
PURPOSE OF REVIEW: This review provides an update on the developments of adjuvant and neoadjuvant liver-directed and systemic therapy options for patients with resectable hepatocellular carcinoma. RECENT FINDINGS: Data on liver-directed treatment in the adjuvant and neoadjuvant settings are sparse and results are conflicting; many studies suggest that optimizing patient selection criteria is a key milestone required to improve study design and clinical benefit to patients. Systemic treatment options are primarily focused on investigation of anti-PD-1/L1 immunotherapeutic agents, either alone or in combination with other drugs. Numerous clinical trials in both adjuvant and neoadjuvant settings are in progress. Exploration of liver-directed and systemic treatment options for adjuvant and neoadjuvant treatment of patients with resectable hepatocellular carcinoma has the potential to improve clinical outcomes for this patient population.
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MEDLINE
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En
Ano de publicação:
2023
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Article