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Functional assay for assessment of agonistic or antagonistic activity of angiotensin AT2 receptor ligands reveals that EMA401 and PD123319 have agonistic properties.
Peluso, A Augusto; Souza-Silva, Igor M; Villela, Daniel C; Hansen, Pernille B L; Hallberg, Anders; Bader, Michael; Santos, Robson; Sumners, Colin; Steckelings, U Muscha.
Afiliação
  • Peluso AA; IMM - Department of Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
  • Souza-Silva IM; IMM - Department of Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark.
  • Villela DC; Faculty of Medicine, University of the Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina, Brazil.
  • Hansen PBL; IMM - Department of Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark.
  • Hallberg A; Department of Medicinal Chemistry, BMC, Uppsala University, Uppsala, Sweden.
  • Bader M; Max Delbrück Center for Molecular Medicine, Berlin, Germany; Charité-Universitätsmedizin Berlin, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Germany; Institute for Biology, University of Lübeck, Germany.
  • Santos R; National Institute of Science and Technology in Nanobiopharmaceutics, Department of Physiology and Biophysics, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
  • Sumners C; Department of Physiology and Aging, University of Florida, Gainesville, USA.
  • Steckelings UM; IMM - Department of Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark. Electronic address: usteckelings@health.sdu.dk.
Biochem Pharmacol ; 216: 115793, 2023 10.
Article em En | MEDLINE | ID: mdl-37689272
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Endoteliais / Receptor Tipo 2 de Angiotensina Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células Endoteliais / Receptor Tipo 2 de Angiotensina Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article