Got PIDD1? Natural killer cells clear polyploid cells to ensure a balanced genome.
EMBO J
; 42(20): e115307, 2023 10 16.
Article
em En
| MEDLINE
| ID: mdl-37691515
ABSTRACT
Removal of polyploid cells is essential to preventing cancer and restricting tumor growth. A new study published in The EMBO Journal shows assembly of the NEMO-PIDDosome on extra centrioles. Activation of this protein complex leads to NF-κB activation that, in turn, induces NK cell-mediated cell clearance.
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1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
NF-kappa B
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article