Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal.
Nat Med
; 29(10): 2509-2517, 2023 10.
Article
em En
| MEDLINE
| ID: mdl-37696933
ABSTRACT
Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the highest impact on case numbers and fitted them into a global context, finding evidence that several international sublineages probably emerged or spread early in Portugal. We estimated a 62% infection reporting rate and that 1.3% of the population of men who have sex with men in Portugal were infected. We infer the critical role played by sexual networks and superspreader gatherings, such as sauna attendance, in the dissemination of mpox virus. Overall, our findings highlight genomic epidemiology as a tool for the real-time monitoring and control of mpox epidemics, and can guide future vaccine policy in a highly susceptible population.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mpox
/
Minorias Sexuais e de Gênero
Tipo de estudo:
Prognostic_studies
Limite:
Humans
/
Male
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article