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A cleavage rule for selection of increased-fidelity SpCas9 variants with high efficiency and no detectable off-targets.
Kulcsár, Péter István; Tálas, András; Ligeti, Zoltán; Tóth, Eszter; Rakvács, Zsófia; Bartos, Zsuzsa; Krausz, Sarah Laura; Welker, Ágnes; Végi, Vanessza Laura; Huszár, Krisztina; Welker, Ervin.
Afiliação
  • Kulcsár PI; Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.
  • Tálas A; Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.
  • Ligeti Z; Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.
  • Tóth E; Institute of Biochemistry, Biological Research Centre, Szeged, Hungary.
  • Rakvács Z; Doctoral School of Multidisciplinary Medical Science, University of Szeged, Szeged, Hungary.
  • Bartos Z; Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.
  • Krausz SL; Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.
  • Welker Á; Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.
  • Végi VL; Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary.
  • Huszár K; Biospiral-2006 Ltd, Szeged, Hungary.
  • Welker E; School of Ph.D. Studies, Semmelweis University, Budapest, Hungary.
Nat Commun ; 14(1): 5746, 2023 09 16.
Article em En | MEDLINE | ID: mdl-37717069
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptococcus pyogenes / Engenharia Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptococcus pyogenes / Engenharia Idioma: En Ano de publicação: 2023 Tipo de documento: Article