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Bone health in children with recurrent and chronic pancreatitis: A multi-center cross sectional analysis.
Abu-El-Haija, Maisam; Hornung, Lindsey; Ellery, Kate; Fishman, Douglas S; Gonska, Tanja Y; Gariepy, Cheryl; Lowe, Mark; Larson Ode, Katie; Maqbool, Asim; Mascarenhas, Maria; Morinville, Veronique D; Ooi, Chee Y; Perito, Emily R; Schwarzenberg, Sarah Jane; Sellers, Zachary M; Zemel, Babette S; Yuan, Ying; Wang, Fuchenchu; Uc, Aliye; Kalkwarf, Heidi J.
Afiliação
  • Abu-El-Haija M; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: maisam.haija@cchmc.org.
  • Hornung L; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
  • Ellery K; Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Fishman DS; Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
  • Gonska TY; Hospital for Sick Children, Toronto, ON, Canada.
  • Gariepy C; Nationwide Children's Hospital, Columbus, OH, USA.
  • Lowe M; Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO, USA.
  • Larson Ode K; Department of Pediatrics, University of Iowa, Iowa City, IA, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA.
  • Maqbool A; Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Mascarenhas M; Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Morinville VD; Montreal Children's Hospital, McGill University, Montreal, QC, Canada.
  • Ooi CY; Discipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine and Health, University of New South Wales and Department of Gastroenterology, Sydney Children's Hospital Randwick, Sydney, Australia.
  • Perito ER; University of California San Francisco, San Francisco, CA, USA.
  • Schwarzenberg SJ; University of Minnesota Masonic Children's Hospital, Minneapolis, MN, USA.
  • Sellers ZM; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Stanford University, Palo Alto, CA, USA.
  • Zemel BS; Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
  • Yuan Y; Department of Biostatistics, University of Texas MD, Anderson Cancer Center, Huston, TX, USA.
  • Wang F; Department of Biostatistics, University of Texas MD, Anderson Cancer Center, Huston, TX, USA.
  • Uc A; Department of Pediatrics, University of Iowa, Iowa City, IA, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, USA; Radiation Oncology, University of Iowa, Iowa City, IA, USA.
  • Kalkwarf HJ; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Pancreatology ; 23(7): 755-760, 2023 Nov.
Article em En | MEDLINE | ID: mdl-37723006
ABSTRACT
BACKGROUND/

OBJECTIVES:

Bone health of children with acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) is not well studied.

METHODS:

This retrospective study was performed at three sites and included data from INSPPIRE-2.

RESULTS:

Of the 87 children in the study 46 had ARP (53%), 41 had CP (47%). Mean age was 13.6 ± 3.9 years at last DXA scan. The prevalence of low height-for-age (Z-score < -2) (13%, 10/78) and low bone mineral density (BMD) adjusted for height (Z-score < -2) (6.4%, 5/78) were higher than a healthy reference sample (2.5%, p < 0.0001 and p = 0.03, respectively).

CONCLUSION:

Children with ARP or CP have lower height and BMD than healthy peers. Attention to deficits in growth and bone mineral accrual in children with pancreatic disease is warranted.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Densidade Óssea / Pancreatite Crônica Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Child / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Densidade Óssea / Pancreatite Crônica Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Child / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article