Total serum IgA levels and HLA-DQB1*02:01 allelic status.
Immunol Res
; 72(1): 167-173, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-37725324
ABSTRACT
Immunoglobulin A Deficiency (IgAD) is the most common primary immunodeficiency and is significantly associated with Celiac Disease (CD), which recognizes a specific background of human leukocyte antigens (HLA) predisposition (including HLA-DQB1*0201 allele). A number of studies investigated the role of HLA in IgAD etiopathogenesis HLA-DQB1*02 alleles are included in the main haplotypes linked to this primary immunodeficiency. In this preliminary study, we investigated the potential impact of HLA-DQB1*0201 allelic status on total serum IgA levels 108 serum samples from the bone marrow donors' registry were analyzed for total IgA concentration with respect to the HLA-DQB1*0201 status. Although total serum IgA levels between HLA-DQB1*0201 carriers and HLA-DQB1*0201 negative donors were not different, we observed a statistically significant difference (p=0.0118) in total serum IgA levels among donors with low IgA concentration (<80mg/dL) in the sub-analysis between HLA-DQB1*0201 positive group (including both homozygous and heterozygous carriers) compared to HLA-DQB1*0201 negative donors. Our results might suggest a role of HLA-DQB1*0201 allelic variant in the determination of total serum IgA levels, at least in patients affected with IgA deficiency and/or otherwise predisposed to it; however, larger and more standardized studies are needed to confirm this speculation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Deficiência de IgA
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article