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Joint genotypic and phenotypic outcome modeling improves base editing variant effect quantification.
Ryu, Jayoung; Barkal, Sam; Yu, Tian; Jankowiak, Martin; Zhou, Yunzhuo; Francoeur, Matthew; Phan, Quang Vinh; Li, Zhijian; Tognon, Manuel; Brown, Lara; Love, Michael I; Lettre, Guillaume; Ascher, David B; Cassa, Christopher A; Sherwood, Richard I; Pinello, Luca.
Afiliação
  • Ryu J; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Barkal S; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
  • Yu T; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Jankowiak M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Zhou Y; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Francoeur M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Phan QV; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia.
  • Li Z; Computational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
  • Tognon M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Brown L; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Love MI; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Lettre G; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Ascher DB; Molecular Pathology Unit, Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • Cassa CA; Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Sherwood RI; Computer Science Department, University of Verona, Verona, Italy.
  • Pinello L; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
medRxiv ; 2023 Sep 10.
Article em En | MEDLINE | ID: mdl-37732177
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article