Chemical biology tools for protein labelling: insights into cell-cell communication.
Biochem J
; 480(18): 1445-1457, 2023 09 27.
Article
em En
| MEDLINE
| ID: mdl-37732646
ABSTRACT
Multicellular organisms require carefully orchestrated communication between and within cell types and tissues, and many unicellular organisms also sense their context and environment, sometimes coordinating their responses. This review highlights contributions from chemical biology in discovering and probing mechanisms of cell-cell communication. We focus on chemical tools for labelling proteins in a cellular context and how these can be applied to decipher the target receptor of a signalling molecule, label a receptor of interest in situ to understand its biology, provide a read-out of protein activity or interactions in downstream signalling pathways, or discover protein-protein interactions across cell-cell interfaces.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biologia
/
Comunicação Celular
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article