Genetic diversity and characterization of rhinoviruses from Chinese clinical samples with a global perspective.
Microbiol Spectr
; 11(6): e0084023, 2023 Dec 12.
Article
em En
| MEDLINE
| ID: mdl-37733296
ABSTRACT
IMPORTANCE Based on clinical samples collected in China, we detected and reported 22 types for the first time in China, as well as three types for the first time in Asia, and reported their genetic characteristics and diversity. We identified a novel type of Rhinovirus (RV), A110, highlighting its unique genetic features. We annotated the genomic structure and serotype of all the existing RV sequences in the database, and four novel RV types were identified and their genetic diversity reported. Combined with the sequence annotation, we constructed a complete VP1 data set of RV and conducted the first large-scale evolutionary dynamics analysis of RV. Based on a high-quality data set, we conducted a comprehensive analysis of the guanine-cytosine (GC) content variations among serotypes of RVs. This study provides crucial theoretical support and valuable data for understanding RV's genetic diversity and developing antiviral strategies.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por Picornaviridae
/
Infecções por Enterovirus
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article