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Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization.
Nilsson, Magnus; Berggren, Kristina; Berglund, Susanne; Cerboni, Silvia; Collins, Mia; Dahl, Göran; Elmqvist, David; Grimster, Neil P; Hendrickx, Ramon; Johansson, Johan R; Kettle, Jason G; Lepistö, Matti; Rhedin, Magdalena; Smailagic, Amir; Su, Qibin; Wennberg, Tiiu; Wu, Allan; Österlund, Torben; Naessens, Thomas; Mitra, Suman.
Afiliação
  • Nilsson M; Medicinal Chemistry, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Berggren K; Medicinal Chemistry, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Berglund S; Medicinal Chemistry, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Cerboni S; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Collins M; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Dahl G; Structure and Biophysics, Research and Early Development, Discovery Science, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Elmqvist D; Early Product Development, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Grimster NP; Oncology R&D, AstraZeneca R&D, Waltham, Massachusetts 02451, United States.
  • Hendrickx R; DMPK, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Johansson JR; Medicinal Chemistry, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Kettle JG; Oncology R&D, AstraZeneca R&D, Waltham, Massachusetts 02451, United States.
  • Lepistö M; Medicinal Chemistry, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Rhedin M; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Smailagic A; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Su Q; Oncology R&D, AstraZeneca R&D, Waltham, Massachusetts 02451, United States.
  • Wennberg T; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Wu A; Discovery Sciences, R&D, AstraZeneca R&D, Waltham, Massachusetts 02451, United States.
  • Österlund T; Mechanistic Biology & Profiling, Research and Early Development, Discovery Science, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Naessens T; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
  • Mitra S; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.
J Med Chem ; 66(19): 13400-13415, 2023 Oct 12.
Article em En | MEDLINE | ID: mdl-37738648
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article