Case-Control Trials on Risk Factors for Pancreatic Cancer: A Systematic Review and Meta-Analysis.
Iran J Public Health
; 52(8): 1578-1588, 2023 Aug.
Article
em En
| MEDLINE
| ID: mdl-37744539
ABSTRACT
Background:
The single risk factors of pancreatic cancer (PC) has been extensively studied. We aimed to synthesize results from such studies to identify and estimate multiple independent risk factors of PC.Methods:
Articles published up to Feb 28, 2020 in English or Chinese reporting risk factors of PC were reviewed. The fixed-effects model with 95% confidence interval (CI) were used to calculate the pooled Odds Ratio (OR). Data were analyzed using RevMan 5.3.Results:
PC was significantly associated with smoking (OR 1.76, 95% CI 1.61-1.92, P < 0.00001, I2 = 6%), diabetes (OR 2.69, 95% CI 2.52-2.88, P < 0.00001, I2 = 0%), family history of PC (OR 2.58, 95% CI 2.13-3.11, P < 0.00001, I2 = 0%), and chronic pancreatitis (OR 5.84, 95% CI 3.63-9.41, P < 0.00001, I2 = 0%).Conclusion:
Smoking, diabetes, family history of PC, and chronic pancreatitis were independent risk factors for PC. These independent risk factors have an important role in identifying high-risk groups, which is of great significance to reduce the incidence of PC and improve the quality of life and prognosis of patients.
Texto completo:
1
Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article