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A latent cardiomyocyte regeneration potential in human heart disease.
Derks, Wouter; Rode, Julian; Collin, Sofia; Rost, Fabian; Heinke, Paula; Hariharan, Anjana; Pickel, Lauren; Simonova, Irina; Lázár, Eniko; Graham, Evan; Jashari, Ramadan; Andrä, Michaela; Jeppsson, Anders; Salehpour, Mehran; Alkass, Kanar; Druid, Henrik; Kyriakopoulos, Christos P; Taleb, Iosif; Shankar, Thirupura S; Selzman, Craig H; Sadek, Hesham; Jovinge, Stefan; Brusch, Lutz; Frisén, Jonas; Drakos, Stavros; Bergmann, Olaf.
Afiliação
  • Derks W; Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
  • Rode J; Center of Information Services and High-Performance Computing, TU Dresden, Dresden, Germany.
  • Collin S; Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
  • Rost F; Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
  • Heinke P; Center of Information Services and High-Performance Computing, TU Dresden, Dresden, Germany.
  • Hariharan A; DRESDEN-concept Genome Center, Technology Platform at the Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden, Dresden, Germany.
  • Pickel L; Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
  • Simonova I; Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
  • Lázár E; Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
  • Graham E; Center for Regenerative Therapies Dresden, TU Dresden, Dresden, Germany.
  • Jashari R; Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
  • Andrä M; Department of Cell and Molecular Biology, Karolinska Institute, SE-171 77 Stockholm, Sweden.
  • Jeppsson A; European Homograft Bank, B-1120 Brussels, Belgium.
  • Salehpour M; Department of Cardiothoracic and Vascular Surgery, Klinikum Klagenfurt and Section for Surgical Research Medical University Graz, 9020 Graz, Austria.
  • Alkass K; Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, SE-413 45 Gothenburg, Sweden.
  • Druid H; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Kyriakopoulos CP; Department of Physics and Astronomy, Applied Nuclear Physics, Uppsala University, SE-751 20 Uppsala, Sweden.
  • Taleb I; Department of Oncology-Pathology, Karolinska Institute, SE-171 77 Stockholm and National Board of Forensic Medicine, SE-171 65 Stockholm, Sweden.
  • Shankar TS; Department of Oncology-Pathology, Karolinska Institute, SE-171 77 Stockholm and National Board of Forensic Medicine, SE-171 65 Stockholm, Sweden.
  • Selzman CH; Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.
  • Sadek H; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States.
  • Jovinge S; Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.
  • Brusch L; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States.
  • Frisén J; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States.
  • Drakos S; Divisions of Cardiovascular Medicine and Cardiothoracic Surgery, University of Utah Health & School of Medicine, Salt Lake City, Utah, United States.
  • Bergmann O; Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, Utah, United States.
bioRxiv ; 2023 Sep 17.
Article em En | MEDLINE | ID: mdl-37745322
ABSTRACT
Cardiomyocytes in the adult human heart show a regenerative capacity, with an annual renewal rate around 0.5%. Whether this regenerative capacity of human cardiomyocytes is employed in heart failure has been controversial. Using retrospective 14C birth dating we analyzed cardiomyocyte renewal in patients with end-stage heart failure. We show that cardiomyocyte generation is minimal in end-stage heart failure patients at rates 18-50 times lower compared to the healthy heart. However, patients receiving left ventricle support device therapy, who showed significant functional and structural cardiac improvement, had a >6-fold increase in cardiomyocyte renewal relative to the healthy heart. Our findings reveal a substantial cardiomyocyte regeneration potential in human heart disease, which could be exploited therapeutically.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article