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Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation.
Chawda, Mira M; Ross, Susan; Lau, Ching-In; Yánez, Diana C; Rowell, Jasmine; Kilbride, Peter; Crompton, Tessa.
Afiliação
  • Chawda MM; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Ross S; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Lau CI; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Yánez DC; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Rowell J; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Kilbride P; Cytiva, Danaher Corporation, Cambridge, UK.
  • Crompton T; UCL Great Ormond Street Institute of Child Health, London, UK.
Eur J Immunol ; 53(12): e2350546, 2023 12.
Article em En | MEDLINE | ID: mdl-37751619
Cryopreservation of mouse thymus depletes donor thymocytes but preserves thymus function when transplanted after thawing into athymic mice. No differences in immune reconstitution were observed between fresh and frozen/thawed transplants suggesting that donor thymocyte depletion does not affect outcome. Thus, cryopreservation of thymus may improve outcomes in thymus transplant patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Timócitos / Reconstituição Imune Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Timócitos / Reconstituição Imune Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article