Mortality and exacerbations associated with Stenotrophomonas maltophilia in chronic obstructive pulmonary disease. A regional cohort study of 22,689 outpatients.
Respir Res
; 24(1): 232, 2023 Sep 26.
Article
em En
| MEDLINE
| ID: mdl-37752596
ABSTRACT
OBJECTIVES:
The clinical significance of Stenotrophomonas maltophilia in patients with COPD is poorly understood. We aimed to determine whether a lower respiratory tract culture positive for S. maltophilia in COPD patients was independently associated with increased risk of death and hospitalisation for exacerbation of COPD.METHODS:
An observational cohort study following outpatients with COPD in Eastern Denmark between 2010 and 2018, with a follow-up period of five years. Presence of S. maltophilia was treated as a time-varying exposure, where patients were considered exposed at the time of the first isolation of S. maltophilia from the lower respiratory tract. The hazard ratio (HR) of death and hospitalisation for acute exacerbations of COPD was assessed using a Cox proportional hazards regression.RESULTS:
Of the total 22,689 patients 459 (2.0%) had a lower respiratory sample positive for S. maltophilia. A total of 7,649 deaths (S. maltophilia positive 243 (52.9%) and S. maltophilia negative 7,406 (34.4%)) and 24,912 hospitalisations for exacerbation of COPD (S. maltophilia positive 1,100 in 459 patients and S. maltophilia negative 23,821 in 22,230 patients) were registered during the study period. We found that a lower respiratory tract culture positive for S. maltophilia was associated with both increased mortality HR 3.3 (95% CI 2.6-4.3), and hospitalisation for exacerbation of COPD HR 3.4 (95% CI 2.8-4.1).CONCLUSIONS:
A lower respiratory tract culture positive for S. maltophilia in COPD patients was associated with a substantially increased mortality and hospitalisation for exacerbation of COPD. Randomised controlled trials are proposed to determine whether S. maltophilia should be the target of antibiotic treatment.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Stenotrophomonas maltophilia
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Doença Pulmonar Obstrutiva Crônica
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
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Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article