Pulmonary arterial wedge pressure increase during exercise in patients diagnosed with pulmonary arterial or chronic thromboembolic pulmonary hypertension.
ERJ Open Res
; 9(5)2023 Sep.
Article
em En
| MEDLINE
| ID: mdl-37753275
ABSTRACT
Background:
The course of pulmonary arterial wedge pressure (PAWP) during exercise in patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension (PAH/CTEPH), further abbreviated as pulmonary vascular disease (PVD), is still unknown. The aim of the study was to describe PAWP during exercise in patients with PVD.Methods:
In this cross-sectional study, right heart catheter (RHC) data including PAWP, recorded during semi-supine, stepwise cycle exercise in patients with PVD, were analysed retrospectively. We investigated PAWP changes during exercise until end-exercise.Results:
In 121 patients (59 female, 66 CTEPH, 55 PAH, 62±17â years) resting PAWP was 10.2±4.1 mmHg. Corresponding peak changes in PAWP during exercise were +2.9â mmHg (95% CI 2.1-3.7â mmHg, p<0.001). Patients ≥50â years had a significantly higher increase in PAWP during exercise compared with those <50â years (p<0.001). The PAWP/cardiac output (CO) slopes were 3.9â WU for all patients, and 1.6â WU for patients <50â years and 4.5â WU for those ≥50â years.Conclusion:
In patients with PVD, PAWP increased slightly but significantly with the onset of exercise compared to resting values. The increase in PAWP during exercise was age-dependent, with patients ≥50â years showing a rapid PAWP increase even with minimal exercise. PAWP/CO slopes >2â WU are common in patients with PVD aged ≥50â years without exceeding the PAWP of 25â mmHg during exercise.
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Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article