Relationship Between Short-chain Fatty Acids and Parkinson's Disease: A Review from Pathology to Clinic.
Neurosci Bull
; 40(4): 500-516, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-37755674
ABSTRACT
Parkinson's disease (PD) is a complicated neurodegenerative disease, characterized by the accumulation of α-synuclein (α-syn) in Lewy bodies and neurites, and massive loss of midbrain dopamine neurons. Increasing evidence suggests that gut microbiota and microbial metabolites are involved in the development of PD. Among these, short-chain fatty acids (SCFAs), the most abundant microbial metabolites, have been proven to play a key role in brain-gut communication. In this review, we analyze the role of SCFAs in the pathology of PD from multiple dimensions and summarize the alterations of SCFAs in PD patients as well as their correlation with motor and non-motor symptoms. Future research should focus on further elucidating the role of SCFAs in neuroinflammation, as well as developing novel strategies employing SCFAs and their derivatives to treat PD.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Doenças Neurodegenerativas
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article