Gender differences in patient experience in idiopathic inflammatory myopathies: Sub analysis from the COVAD dataset.

Yoshida, Akira; Kim, Minchul; Kuwana, Masataka; Ravichandran, Naveen; Makol, Ashima; Sen, Parikshit; Lilleker, James B; Agarwal, Vishwesh; Kardes, Sinan; Day, Jessica; Milchert, Marcin; Joshi, Mrudula; Gheita, Tamer; Salim, Babur; Velikova, Tsvetelina; Gracia-Ramos, Abraham Edgar; Parodis, Ioannis; Nikiphorou, Elena; Chatterjee, Tulika; Tan, Ai Lyn; Nune, Arvind; Cavagna, Lorenzo; Saavedra, Miguel A; Shinjo, Samuel Katsuyuki; Ziade, Nelly; Knitza, Johannes; Distler, Oliver; Chinoy, Hector; Agarwal, Vikas; Aggarwal, Rohit; Gupta, Latika

Yoshida, Akira; Kim, Minchul; Kuwana, Masataka; Ravichandran, Naveen; Makol, Ashima; Sen, Parikshit; Lilleker, James B; Agarwal, Vishwesh; Kardes, Sinan; Day, Jessica; Milchert, Marcin; Joshi, Mrudula; Gheita, Tamer; Salim, Babur; Velikova, Tsvetelina; Gracia-Ramos, Abraham Edgar; Parodis, Ioannis; Nikiphorou, Elena; Chatterjee, Tulika; Tan, Ai Lyn; Nune, Arvind; Cavagna, Lorenzo; Saavedra, Miguel A; Shinjo, Samuel Katsuyuki; Ziade, Nelly; Knitza, Johannes; Distler, Oliver; Chinoy, Hector; Agarwal, Vikas; Aggarwal, Rohit; Gupta, Latika.

Afiliação

Yoshida A; Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan.
Kim M; Center for Outcomes Research, Department of Internal Medicine, University of Illinois College of Medicine Peoria, USA.
Kuwana M; Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan.
Ravichandran N; Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Makol A; Division of Rheumatology, Mayo Clinic, Rochester, USA.
Sen P; Maulana Azad Medical College, New Delhi, India.
Lilleker JB; Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
Agarwal V; Neurology, Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust, Salford, UK.
Kardes S; Mahatma Gandhi Mission Medical College, Navi Mumbai, India.
Day J; Department of Medical Ecology and Hydroclimatology, Istanbul Faculty of Medicine, Istanbul University, Capa-Fatih, Turkey.
Milchert M; Department of Rheumatology, Royal Melbourne Hospital, Parkville, Australia.
Joshi M; Walter and Eliza Hall Institute of Medical Research, Parkville, Australia.
Gheita T; Department of Medical Biology, University of Melbourne, Parkville, Australia.
Salim B; Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Velikova T; Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, India.
Gracia-Ramos AE; Rheumatology Department, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt.
Parodis I; Rheumatology Department, Fauji Foundation Hospital, Rawalpindi, Pakistan.
Nikiphorou E; Medical Faculty, Sofia University St. Kliment Ohridski, Sofia, Bulgaria.
Chatterjee T; Department of Internal Medicine, General Hospital, National Medical Center 'La Raza', Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Tan AL; Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Sweden.
Nune A; Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Cavagna L; Centre for Rheumatic Diseases, King's College London, London, UK.
Saavedra MA; Rheumatology Department, King's College Hospital, London, UK.
Shinjo SK; Center for Outcomes Research, Department of Internal Medicine, University of Illinois College of Medicine Peoria, USA.
Ziade N; NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK.
Knitza J; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
Distler O; Southport and Ormskirk Hospital NHS Trust, Southport, UK.
Chinoy H; Department of Rheumatology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy.
Agarwal V; Rheumatology Unit, Dipartimento di Medicine Interna e Terapia Medica, Università degli studi di Pavia, Pavia, Italy.
Aggarwal R; Departamento de Reumatología Hospital de Especialidades Dr. Antonio Fraga Mouret, Centro Médico Nacional La Raza, IMSS, Mexico City, Mexico.
Gupta L; Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil.

Mod Rheumatol ; 2023 Sep 28.

Article em En | MEDLINE | ID: mdl-37769200

ABSTRACT

ABSTRACT

OBJECTIVES:

We aimed to investigate gender-based differences in idiopathic inflammatory myopathies (IIMs), with a particular focus on patient-reported outcomes, utilizing data obtained through the international COVID-19 vaccination in autoimmune disease (COVAD) e-survey.

METHODS:

Patient-reported outcomes including fatigue, pain, and physical function were extracted from the COVAD database and compared between genders, adjusting for demographics and IIM subgroups by multivariable analysis. Inclusion body myositis (IBM) was analysed separately because of substantial differences in outcomes.

RESULTS:

1197 complete responses from patients with IIMs as of 31 August 2021 were analysed. Seventy percent were women. Women were younger (58 [48-68] vs. 69 [58-75] years old, median [IQR], p < 0.001) and more likely to suffer from autoimmune multimorbidity, defined as three or more autoimmune diseases in an individual patient (11.4% vs. 2.8%, p < 0.001). In non-IBM IIMs, fatigue visual analogue scale scores were higher in women (5 [3-7] vs. 4 [2-6], median [IQR], p = 0.004), whereas no significant gender-based differences were noted in IBM. Multivariable analysis in non-IBM IIMs revealed women, residence in high-income countries, overlap myositis, and autoimmune multimorbidity were independently associated with increased fatigue.