Model-directed generation of CRISPR-Cas13a guide RNAs designs artificial sequences that improve nucleic acid detection.

Mantena, Sreekar; Pillai, Priya P; Petros, Brittany A; Welch, Nicole L; Myhrvold, Cameron; Sabeti, Pardis C; Metsky, Hayden C

Mantena, Sreekar; Pillai, Priya P; Petros, Brittany A; Welch, Nicole L; Myhrvold, Cameron; Sabeti, Pardis C; Metsky, Hayden C.

Afiliação

Mantena S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Pillai PP; Department of Statistics, Harvard University, Cambridge, MA, USA.
Petros BA; Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
Welch NL; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Myhrvold C; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Sabeti PC; Division of Health Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology, Cambridge, MA, USA.
Metsky HC; Harvard/Massachusetts Institute of Technology, MD-PhD Program, Boston, MA, USA.

bioRxiv ; 2023 Sep 20.

Article em En | MEDLINE | ID: mdl-37786711

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article