Preclinical Pharmacokinetics and Translational Pharmacokinetic/Pharmacodynamic Modeling of M8891, a Potent and Reversible Inhibitor of Methionine Aminopeptidase 2.

Lignet, Floriane; Friese-Hamim, Manja; Jaehrling, Frank; El Bawab, Samer; Rohdich, Felix

Lignet, Floriane; Friese-Hamim, Manja; Jaehrling, Frank; El Bawab, Samer; Rohdich, Felix.

Afiliação

Lignet F; Drug Discovery Technologies, the Healthcare Business of Merck KGaA, 250 Frankfurter Strasse, 64293, Darmstadt, Germany. floriane.lignet@emdgroup.com.
Friese-Hamim M; Research Unit Oncology, the Healthcare Business of Merck KGaA, Darmstadt, Germany.
Jaehrling F; Research Unit Oncology, the Healthcare Business of Merck KGaA, Darmstadt, Germany.
El Bawab S; Translational Medicine, the Healthcare Business of Merck KGaA, Darmstadt, Germany.
Rohdich F; Translational Medicine, Servier, Suresnes, France.

Pharm Res ; 40(12): 3011-3023, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37798538

Assuntos

Metaloendopeptidases; Modelos Biológicos; Humanos; Camundongos; Animais; Inibidores da Angiogênese; Inibidores Enzimáticos

Palavras-chave

PK/PD; allometry; human PK prediction; translational modeling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Metaloendopeptidases / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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