Cooperation of ILC2s and TH2 cells in the expulsion of intestinal helminth parasites.
Nat Rev Immunol
; 24(4): 294-302, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-37798539
ABSTRACT
Type 2 immune responses form a critical defence against enteric worm infections. In recent years, mouse models have revealed shared and unique functions for group 2 innate lymphoid cells and T helper 2 cells in type 2 immune response to intestinal helminths. Both cell types use similar innate effector functions at the site of infection, whereas each population has distinct roles during different stages of infection. In this Perspective, we review the underlying mechanisms used by group 2 innate lymphoid cells and T helper 2 cells to cooperate with each other and suggest an overarching model of the interplay between these cell types over the course of a helminth infection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Parasitos
/
Helmintíase
/
Helmintos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article