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Gain without pain: adaptation and increased virulence of Zika virus in vertebrate host without fitness cost in mosquito vector.
Jaeger, Anna S; Marano, Jeffrey; Riemersma, Kasen K; Castaneda, David; Pritchard, Elise M; Pritchard, Julia C; Bohm, Ellie K; Baczenas, John J; O'Connor, Shelby L; Weger-Lucarelli, James; Friedrich, Thomas C; Aliota, Matthew T.
Afiliação
  • Jaeger AS; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.
  • Marano J; Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University , Blacksburg, Virginia, USA.
  • Riemersma KK; Department of Pathobiological Sciences, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Castaneda D; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.
  • Pritchard EM; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.
  • Pritchard JC; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.
  • Bohm EK; Department of Veterinary and Biomedical Sciences, University of Minnesota , Twin Cities, Minnesota, USA.
  • Baczenas JJ; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • O'Connor SL; Wisconsin National Primate Research Center, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Weger-Lucarelli J; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Friedrich TC; Wisconsin National Primate Research Center, University of Wisconsin-Madison , Madison, Wisconsin, USA.
  • Aliota MT; Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University , Blacksburg, Virginia, USA.
J Virol ; 97(10): e0116223, 2023 10 31.
Article em En | MEDLINE | ID: mdl-37800949
ABSTRACT
IMPORTANCE Previously, we modeled direct transmission chains of Zika virus (ZIKV) by serially passaging ZIKV in mice and mosquitoes and found that direct mouse transmission chains selected for viruses with increased virulence in mice and the acquisition of non-synonymous amino acid substitutions. Here, we show that these same mouse-passaged viruses also maintain fitness and transmission capacity in mosquitoes. We used infectious clone-derived viruses to demonstrate that the substitution in nonstructural protein 4A contributes to increased virulence in mice.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Virulência / Aptidão Genética / Zika virus / Mosquitos Vetores / Culicidae Tipo de estudo: Health_economic_evaluation / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Virulência / Aptidão Genética / Zika virus / Mosquitos Vetores / Culicidae Tipo de estudo: Health_economic_evaluation / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article