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National, regional, and global estimates of preterm birth in 2020, with trends from 2010: a systematic analysis.
Ohuma, Eric O; Moller, Ann-Beth; Bradley, Ellen; Chakwera, Samuel; Hussain-Alkhateeb, Laith; Lewin, Alexandra; Okwaraji, Yemisrach B; Mahanani, Wahyu Retno; Johansson, Emily White; Lavin, Tina; Fernandez, Diana Estevez; Domínguez, Giovanna Gatica; de Costa, Ayesha; Cresswell, Jenny A; Krasevec, Julia; Lawn, Joy E; Blencowe, Hannah; Requejo, Jennifer; Moran, Allisyn C.
Afiliação
  • Ohuma EO; Maternal, Adolescent, Reproductive and Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, UK. Electronic address: eric.ohuma@lshtm.ac.uk.
  • Moller AB; Human Reproduction Program (the UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
  • Bradley E; Maternal, Adolescent, Reproductive and Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, UK.
  • Chakwera S; Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, USA.
  • Hussain-Alkhateeb L; Global Health, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Lewin A; Department of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK.
  • Okwaraji YB; Maternal, Adolescent, Reproductive and Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, UK.
  • Mahanani WR; Department of Data and Analytics, World Health Organization, Geneva, Switzerland.
  • Johansson EW; Department of Women and Children's Health, Uppsala University, Uppsala, Sweden.
  • Lavin T; Human Reproduction Program (the UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
  • Fernandez DE; Division of Data, Analytics and Delivery for Impact, World Health Organization, Geneva, Switzerland.
  • Domínguez GG; Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland.
  • de Costa A; Department of Maternal, Newborn, Child and Adolescent Health and Ageing, World Health Organization, Geneva, Switzerland.
  • Cresswell JA; Human Reproduction Program (the UNDP/UNFPA/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction), Department of Sexual and Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
  • Krasevec J; Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, USA.
  • Lawn JE; Maternal, Adolescent, Reproductive and Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, UK.
  • Blencowe H; Maternal, Adolescent, Reproductive and Child Health (MARCH) Centre, London School of Hygiene & Tropical Medicine, London, UK.
  • Requejo J; Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, USA.
  • Moran AC; Department of Maternal, Newborn, Child and Adolescent Health and Ageing, World Health Organization, Geneva, Switzerland.
Lancet ; 402(10409): 1261-1271, 2023 10 07.
Article em En | MEDLINE | ID: mdl-37805217
ABSTRACT

BACKGROUND:

Preterm birth is the leading cause of neonatal mortality and is associated with long-term physical, neurodevelopmental, and socioeconomic effects. This study updated national preterm birth rates and trends, plus novel estimates by gestational age subgroups, to inform progress towards global health goals and targets, and aimed to update country, regional, and global estimates of preterm birth for 2020 in addition to trends between 2010 and 2020.

METHODS:

We systematically searched population-based, nationally representative data on preterm birth from Jan 1, 2010, to Dec 31, 2020 and study data (26 March-14 April, 2021) for countries and areas with no national-level data. The analysis included 679 data points (86% nationally representative administrative data [582 of 679 data points]) from 103 countries and areas (62% of countries and areas having nationally representative administrative data [64 of 103 data points]). A Bayesian hierarchical regression was used for estimating country-level preterm rates, which incoporated country-specific intercepts, low birthweight as a covariate, non-linear time trends, and bias adjustments based on a data quality categorisation, and other indicators such as method of gestational age estimation.

FINDINGS:

An estimated 13·4 million (95% credible interval [CrI] 12·3-15·2 million) newborn babies were born preterm (<37 weeks) in 2020 (9·9% of all births [95% CrI 9·1-11·2]) compared with 13·8 million (12·7-15·5 million) in 2010 (9·8% of all births [9·0-11·0]) worldwide. The global annual rate of reduction was estimated at -0·14% from 2010 to 2020. In total, 55·6% of total livebirths are in southern Asia (26·8% [36 099 000 of 134 767 000]) and sub-Saharan Africa (28·7% [38 819 300 of 134 767 000]), yet these two regions accounted for approximately 65% (8 692 000 of 13 376 200) of all preterm births globally in 2020. Of the 33 countries and areas in the highest data quality category, none were in southern Asia or sub-Saharan Africa compared with 94% (30 of 32 countries) in high-income countries and areas. Worldwide from 2010 to 2020, approximately 15% of all preterm births occurred at less than 32 weeks of gestation, requiring more neonatal care (<28 weeks 4·2%, 95% CI 3·1-5·0, 567 800 [410 200-663 200 newborn babies]); 28-32 weeks 10·4% [9·5-10·6], 1 392 500 [1 274 800-1 422 600 newborn babies]).

INTERPRETATION:

There has been no measurable change in preterm birth rates over the last decade at global level. Despite increasing facility birth rates and substantial focus on routine health data systems, there remain many missed opportunities to improve preterm birth data. Gaps in national routine data for preterm birth are most marked in regions of southern Asia and sub-Saharan Africa, which also have the highest estimated burden of preterm births. Countries need to prioritise programmatic investments to prevent preterm birth and to ensure evidence-based quality care when preterm birth occurs. Investments in improving data quality are crucial so that preterm birth data can be improved and used for action and accountability processes.

FUNDING:

The Children's Investment Fund Foundation and the UNDP, United Nations Population Fund-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nascimento Prematuro Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Child / Female / Humans / Infant / Newborn Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nascimento Prematuro Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Child / Female / Humans / Infant / Newborn Idioma: En Ano de publicação: 2023 Tipo de documento: Article