Organocatalytic allylic alkylation of alkyne-substituted MBH carbonates: access to quaternary carbon-containing 1,4-enynes.
Org Biomol Chem
; 21(41): 8263-8266, 2023 Oct 25.
Article
em En
| MEDLINE
| ID: mdl-37807637
ABSTRACT
A DABCO-catalyzed allylic alkylation of tertiary propargylic alcohol-derived MBH carbonates with nitromethane was developed. A series of substituted 1,4-enynes with an all-carbon quaternary stereocenter were efficiently obtained in moderate to high yields. The synthetic utility of the product was demonstrated by facile synthesis of 1,4-enyne-embedded 2-pyrrolidinones.
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MEDLINE
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article