Palmatine attenuates LPS-induced neuroinflammation through the PI3K/Akt/NF-&#954;B pathway.

Zeng, Jianning; Pei, Hongyan; Wu, Hong; Chen, Weijia; Du, Rui; He, Zhongmei

Palmatine attenuates LPS-induced neuroinflammation through the PI3K/Akt/NF-κB pathway.

Zeng, Jianning; Pei, Hongyan; Wu, Hong; Chen, Weijia; Du, Rui; He, Zhongmei.

Afiliação

Zeng J; Department of Agriculture and Rural Affairs of Jilin Province Pharmacy and Pharmaceutical Science and Technology, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, Jilin, China.
Pei H; Department of Agriculture and Rural Affairs of Jilin Province Pharmacy and Pharmaceutical Science and Technology, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, Jilin, China.
Wu H; Department of Agriculture and Rural Affairs of Jilin Province Pharmacy and Pharmaceutical Science and Technology, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, Jilin, China.
Chen W; Department of Agriculture and Rural Affairs of Jilin Province Pharmacy and Pharmaceutical Science and Technology, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, Jilin, China.
Du R; Department of Science and Technology of Jilin Province, Department of Traditional Chinese Medicine Industry in Xinjiang, Engineering Research Center for High-Efficiency Breeding and Product Development Technology of Sika Deer, Jilin, China.
He Z; Department of Agriculture and Rural Affairs of Jilin Province Pharmacy and Pharmaceutical Science and Technology, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, Jilin, China.

J Biochem Mol Toxicol ; 38(1): e23544, 2024 Jan.

Article em En | MEDLINE | ID: mdl-37815058

Assuntos

Alcaloides de Berberina; NF-kappa B; Proteínas Proto-Oncogênicas c-akt; Camundongos; Animais; NF-kappa B/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Lipopolissacarídeos/toxicidade; Fator de Necrose Tumoral alfa/metabolismo; Doenças Neuroinflamatórias; Interleucina-6; Acetilcolinesterase; Simulação de Acoplamento Molecular

Palavras-chave

LPS neuroinflammation; PI3K/AKT/NFkB; blood-brain barrier; molecular dynamics simulations

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alcaloides de Berberina / NF-kappa B / Proteínas Proto-Oncogênicas c-akt Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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