Your browser doesn't support javascript.
loading
Evaluation of natural resveratrol multimers as marine antifoulants.
Davis, Rohan A; Cervin, Gunnar; Beattie, Karren D; Rali, Topul; Fauchon, Marilyne; Hellio, Claire; Bodin Åkerlund, Lovisa; Pavia, Henrik; Svenson, Johan.
Afiliação
  • Davis RA; Griffith Institute for Drug Discovery, School of Environment and Science, Griffith University, Brisbane, QLD, Australia.
  • Cervin G; Department of Marine Sciences - Tjärnö, University of Gothenburg, Strömstad, Sweden.
  • Beattie KD; Griffith Institute for Drug Discovery, School of Environment and Science, Griffith University, Brisbane, QLD, Australia.
  • Rali T; School of Natural and Physical Sciences, The University of Papua New Guinea, Port Moresby, Papua New Guinea.
  • Fauchon M; Laboratoire des Sciences de l'Environnement MARin (LEMAR), CNRS, IRD, IFREMER, University of Brest, Brest, France.
  • Hellio C; Laboratoire des Sciences de l'Environnement MARin (LEMAR), CNRS, IRD, IFREMER, University of Brest, Brest, France.
  • Bodin Åkerlund L; Department of Biological Function, RISE Research Institutes of Sweden, Borås, Sweden.
  • Pavia H; Department of Marine Sciences - Tjärnö, University of Gothenburg, Strömstad, Sweden.
  • Svenson J; Cawthron Institute, Nelson, New Zealand.
Biofouling ; 39(8): 775-784, 2023.
Article em En | MEDLINE | ID: mdl-37822262
ABSTRACT
In the current study we investigate the antifouling potential of three polyphenolic resveratrol multimers (-)-hopeaphenol, vaticanol B and vatalbinoside A, isolated from two species of Anisoptera found in the Papua New Guinean rainforest. The compounds were evaluated against the growth and settlement of eight marine microfoulers and against the settlement and metamorphosis of Amphibalanus improvisus barnacle cyprids. The two isomeric compounds (-)-hopeaphenol and vaticanol B displayed a high inhibitory potential against the cyprid larvae metamorphosis at 2.8 and 1.1 µM. (-)-Hopeaphenol was also shown to be a strong inhibitor of both microalgal and bacterial adhesion at submicromolar concentrations with low toxicity. Resveratrol displayed a lower antifouling activity compared to the multimers and had higher off target toxicity against MCR-5 fibroblasts. This study illustrates the potential of natural products as a valuable source for the discovery of novel antifouling leads with low toxicity.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Thoracica / Biofilmes Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Thoracica / Biofilmes Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article