Transgenic Mice Expressing Functional TCRs Specific to Cardiac Myhc-&#945; 334-352 on Both CD4 and CD8 T Cells Are Resistant to the Development of Myocarditis on C57BL/6 Genetic Background.

Sur, Meghna; Rasquinha, Mahima T; Arumugam, Rajkumar; Massilamany, Chandirasegaran; Gangaplara, Arunkumar; Mone, Kiruthiga; Lasrado, Ninaad; Yalaka, Bharathi; Doiphode, Aakash; Gurumurthy, Channabasavaiah; Steffen, David; Reddy, Jay

Transgenic Mice Expressing Functional TCRs Specific to Cardiac Myhc-α 334-352 on Both CD4 and CD8 T Cells Are Resistant to the Development of Myocarditis on C57BL/6 Genetic Background.

Sur, Meghna; Rasquinha, Mahima T; Arumugam, Rajkumar; Massilamany, Chandirasegaran; Gangaplara, Arunkumar; Mone, Kiruthiga; Lasrado, Ninaad; Yalaka, Bharathi; Doiphode, Aakash; Gurumurthy, Channabasavaiah; Steffen, David; Reddy, Jay.

Afiliação

Sur M; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Rasquinha MT; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Arumugam R; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Massilamany C; Bristol Myers Squibb, Summit, NJ 07901, USA.
Gangaplara A; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Mone K; CRISPR Therapeutics, Boston, MA 02127, USA.
Lasrado N; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Yalaka B; Miltenyi Biotec, Gaithersburg, MD 20878, USA.
Doiphode A; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Gurumurthy C; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Steffen D; Center for Virology and Vaccine Research, Harvard Medical School, Boston, MA 02115, USA.
Reddy J; School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.

Cells ; 12(19)2023 09 25.

Article em En | MEDLINE | ID: mdl-37830560

Assuntos

Miocardite; Humanos; Camundongos; Animais; Criança; Adolescente; Miocardite/genética; Camundongos Transgênicos; Cadeias Pesadas de Miosina/genética; Camundongos Endogâmicos C57BL; Linfócitos T CD8-Positivos; Receptores de Antígenos de Linfócitos T

Palavras-chave

TCR transgenic mice; cardiac myosin-α 334352; inflammatory cardiomyopathy; myocarditis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Miocardite Limite: Adolescent / Animals / Child / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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